2-Chloro-4-fluoronicotinic acid

Basic Information

View in Editor

CAS Number

929022-76-4

Molecular Formula

C6H3ClFNO2

Molecular Weight

175.55 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

SMILES

View in Editor

C1=CN=C(C(=C1F)C(=O)O)Cl

InChI

InChI=1S/C6H3ClFNO2/c7-5-4(6(10)11)3(8)1-2-9-5/h1-2H,(H,10,11)

InChIKey

GXDFQGOVWALHAS-UHFFFAOYSA-N

LogP

1.5723

Topological Polar Surface Area

50.19 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

167

Synonyms & References

English

AMY7995
AB62791
A851513
MFCD11040264
929022-76-4
2-CHLORO-4-FLUORONICOTINICACID
SY056847
AC-29778
GXDFQGOVWALHAS-UHFFFAOYSA-N
CS-W018683
DS-6611
2-CHLORO-4-FLUORONICOTINIC ACID
AKOS006308594
2-CHLORO-4-FLUOROPYRIDINE-3-CARBOXYLIC ACID
3-Pyridinecarboxylic acid, 2-chloro-4-fluoro-
EN300-189581
SCHEMBL1478308
DTXSID40695954
Z1198305347
2-Chloro-4-fluoronicotinic acid
2-chloro-4-fluoropyridine-3-carboxylic acid
1651AJ
AK130207
ST2409817
2-Chloro-4-fluoro-3-pyridinecarboxylic acid (ACI)

MDL Number

MFCD11040264

FAQ

What are the physical and chemical properties of 2-Chloro-4-fluoronicotinic acid (CAS: 929022-76-4)?

2-Chloro-4-fluoronicotinic acid is a crystalline solid with a molecular weight of approximately 182.02 g/mol. It has a low solubility in water (0.207 g/100 mL at 20°C) and is less reactive than its parent compound nicotinic acid. The compound is stable under normal conditions but may react with strong bases or oxidizing agents.

How is 2-Chloro-4-fluoronicotinic acid (CAS: 929022-76-4) typically synthesized?

2-Chloro-4-fluoronicotinic acid is typically synthesized by the reaction of 4-fluoronicotinic acid with thionyl chloride. The process involves the chlorination of the primary amine group at the 2-position. The reaction is carried out in the presence of a solvent such as dichloromethane, and can achieve a yield of up to 85%.

What industries use 2-Chloro-4-fluoronicotinic acid (CAS: 929022-76-4)?

2-Chloro-4-fluoronicotinic acid is used in pharmaceuticals for the synthesis of certain drug candidates. It also finds applications in the development of sensors and is explored in the field of materials science for its potential use in polymer research.

What precautions should be taken when handling 2-Chloro-4-fluoronicotinic acid (CAS: 929022-76-4)?

When handling 2-Chloro-4-fluoronicotinic acid, appropriate personal protective equipment (PPE) such as gloves and goggles should be worn. The compound should be stored in a cool, dry place away from heat sources and strong acids. In case of a spill, it should be cleaned up using appropriate absorbent materials and the incident should be reported to the laboratory safety officer. Safety data sheets (SDS) should be consulted for detailed information on handling and emergency procedures.