Compound Q&A

How is 2-Chloro-4-methoxynicotinaldehyde (CAS: 905563-79-3) typically synthesized?

Answer

2-Chloro-4-methoxynicotinaldehyde
2-Chloro-4-methoxynicotinaldehyde can be synthesized via the reaction of 4-hydroxy-2-chloronicotinaldehyde with methanol in the presence of a catalytic amount of phosphoric acid. The yield is typically around 85%, and the reaction is highly selective. The product can be purified by recrystallization from water or suitable organic solvents.

About

English Name 2-Chloro-4-methoxynicotinaldehyde
Molecular Formula C7H6ClNO2
Molecular Weight 171.58 g/mol
SMILES COC1=C(C(=NC=C1)Cl)C=O
InChIKey BDKGCVNNWDEUKG-UHFFFAOYSA-N
Last Updated: 2026-01-01 15:34

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