(2-Chlorophenyl)methanesulfonyl chloride(CAS: 77421-13-7)

(2-Chlorophenyl)methanesulfonyl chloride is a white crystalline solid with a molecular weight of approximately 220.59 g/mol. It has low water solubility but good solubility in organic solvents like dichloromethane and acetone. This compound is highly reactive, particularly with primary amines and alcohols. It is used in organic synthesis for its sulfonating properties.

(2-Chlorophenyl)methanesulfonyl chloride is usually synthesized by the reaction of 2-chlorophenylmethanol with thionyl chloride in the presence of an appropriate solvent like dichloromethane. This process requires careful temperature control and is often catalyzed to improve yield and selectivity.

(2-Chlorophenyl)methanesulfonyl chloride is used in the pharmaceutical industry for synthesizing intermediates, in the polymer industry for modifying polymers, and in the semiconductor industry for fabricating electronic components. It is also utilized in the sensor industry for developing gas sensors.

When handling (2-Chlorophenyl)methanesulfonyl chloride, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a fume hood to minimize exposure to vapor. Spills should be handled by professional personnel with appropriate safety measures in place, and the substance should be stored in a cool, dry place away from heat sources. Safety data sheets (SDS) should be consulted for detailed handling instructions.