5-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-2-fluorobenzaldehyde(CAS: 113984-67-1)

5-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-2-fluorobenzaldehyde is a crystalline solid with a molecular weight of approximately 346.44 g/mol. It is slightly soluble in common organic solvents like ethanol and acetone. Chemically, it is known for its reactivity towards nucleophiles and its ability to participate in electrophilic aromatic substitution reactions. It has good stability under neutral to slightly acidic conditions, but it is sensitive to strong bases and oxidizing agents.

5-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-2-fluorobenzaldehyde is typically synthesized through a silylation reaction of 2-fluorobenzaldehyde with dimethyl(2-methyl-2-propanyl)silyl chloride in the presence of a base such as imidazole. The reaction is carried out under anhydrous conditions to avoid hydrolysis. The yield is generally high, and the product shows good selectivity towards the desired silyl ether functionality.

5-{[Dimethyl(2-methyl-2-proanyl)silyl]oxy}-2-fluorobenzaldehyde is used in the pharmaceutical industry for the synthesis of certain drug molecules due to its functional groups, which can be further modified to introduce various pharmacophores. It also finds applications in the polymer industry for the development of functional polymers and in the semiconductor industry for the production of organic electronic materials.

When handling 5-{[Dimethyl(2-methyl-2-proanyl)silyl]oxy}-2-fluorobenzaldehyde, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The work should be carried out in a well-ventilated fume hood to minimize exposure to vapors. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly flushed with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.