6-Chloro-2-quinolinecarboxylic acid(CAS: 59394-30-8)

6-Chloro-2-quinolinecarboxylic acid (CAS: 59394-30-8) is a crystalline solid with a molecular weight of approximately 200.58 g/mol. It is slightly soluble in water and ethanol. Chemically, it is highly reactive, particularly with nucleophiles due to the presence of the carboxylic acid group and the electron-withdrawing chlorine atom. It also exhibits acidic properties in aqueous solutions.

6-Chloro-2-quinolinecarboxylic acid (CAS: 59394-30-8) is typically synthesized via the condensation of 2-quinolinecarboxylic acid with thionyl chloride in the presence of a base like triethylamine. The reaction proceeds through an acyl chloride intermediate, followed by acidification to yield the desired acid. The yield is generally good, around 85-90%, with minimal by-products.

6-Chloro-2-quinolinecarboxylic acid (CAS: 59394-30-8) is used in the pharmaceutical industry as a precursor for the synthesis of certain bioactive compounds. It also finds applications in the development of sensors due to its reactivity and can be used in the production of semiconductors for its electronic properties.

When handling 6-Chloro-2-quinolinecarboxylic acid (CAS: 59394-30-8), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a closed container away from heat and ignition sources. Spills should be cleaned up using appropriate safety measures, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.