Methyl 3-(4-hydroxyphenyl)-4-hexynoate(CAS: 865234-02-2)

Methyl 3-(4-hydroxyphenyl)-4-hexynoate is a crystalline solid with a molecular weight of approximately 212.23 g/mol. It is slightly soluble in water but highly soluble in organic solvents like ethanol and acetone. The compound is reactive, showing susceptibility to hydrolysis and oxidation under certain conditions. It has a melting point around 70-72°C and is stable under normal conditions but requires storage in a cool, dry place away from direct sunlight and oxidizing agents.

Methyl 3-(4-hydroxyphenyl)-4-hexynoate is typically synthesized via a Grignard reaction. The process involves the formation of a Grignard reagent from 4-hydroxybenzaldehyde and hexanoylmagnesium bromide, followed by esterification with methyl alcohol. Common catalysts and reagents include sodium hydride or lithium aluminum hydride to control the reactivity and selectivity. The reaction typically yields 80-90% of the desired product with minimal side products.

Methyl 3-(4-hydroxyphenyl)-4-hexynoate is used in various industries. It finds applications in the pharmaceutical industry as a precursor in the synthesis of certain drugs. It is also utilized in the polymer industry for the development of specific polymers with unique properties. Additionally, it is employed in the sensor industry due to its reactivity and in semiconductor manufacturing for specific chemical processes.

When handling Methyl 3-(4-hydroxyphenyl)-4-hexynoate, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a fume hood to minimize inhalation risks. In case of a spill, it should be carefully cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.