5-Bromo-8-methoxy-2-methylquinoline(CAS: 103862-55-1)

5-Bromo-8-methoxy-2-methylquinoline (CAS: 103862-55-1) is a crystalline solid with a molecular weight of approximately 265.04 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. The compound is moderately reactive, particularly towards nucleophiles and electrophiles, and can undergo substitution reactions under mild conditions.

5-Bromo-8-methoxy-2-methylquinoline is typically synthesized through a multistep process involving alkylation of 8-hydroxy-2-methylquinoline followed by bromination. The synthesis often uses bromine in pyridine as a brominating agent, and the reaction is carried out under nitrogen to avoid oxidation. The overall yield is moderate, around 60-70%, with good selectivity towards the brominated product.

5-Bromo-8-methoxy-2-methylquinoline (CAS: 103862-55-1) finds applications in the pharmaceutical industry for the synthesis of certain bioactive compounds. It is also used in the preparation of sensors and semiconductors due to its electronic properties. Additionally, it is relevant in the polymer industry for the development of novel functional materials.

When handling 5-Bromo-8-methoxy-2-methylquinoline (CAS: 103862-55-1), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or within a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents, and the area should be washed down. Always refer to the Safety Data Sheet (SDS) for specific handling and emergency procedures.