(6-chloro-2-fluoro-3-methoxy-phenyl)boronic acid(CAS: 867333-04-8)

The compound (6-chloro-2-fluoro-3-methoxy-phenyl)boronic acid has a crystalline form with a molecular weight of approximately 255.04 g/mol. It is slightly soluble in water and organic solvents. Chemically, it is reactive in aqueous solutions and can undergo boronate ester formation. The compound is stable under normal storage conditions but requires protection from moisture and light.

(6-Chloro-2-fluoro-3-methoxy-phenyl)boronic acid can be synthesized using a two-step process involving the protection of the methoxy group, followed by boronation with a boronic ester. Commonly, the synthesis involves the use of a palladium catalyst and a phase transfer catalyst. The yield is typically around 70-80%, with good selectivity towards the desired product.

(6-Chloro-2-fluoro-3-methoxy-phenyl)boronic acid is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of drugs and polymers. Additionally, it has applications in the development of sensors and semiconductors due to its unique chemical properties.

When handling (6-chloro-2-fluoro-3-methoxy-phenyl)boronic acid, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area, preferably a fume hood, to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents and disposed of according to local regulations. The safety data sheet (SDS) should always be referenced for detailed handling instructions.