Ethyl 7-nitro-1H-indole-2-carboxylate(CAS: 6960-46-9)

Ethyl 7-nitro-1H-indole-2-carboxylate (CAS: 6960-46-9) is a crystalline solid with a molecular weight of approximately 263.15 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. This compound is known for its moderate reactivity, particularly in nucleophilic substitution and elimination reactions. It has a high melting point and is stable under normal laboratory conditions.

Ethyl 7-nitro-1H-indole-2-carboxylate (CAS: 6960-46-9) is typically synthesized via a condensation reaction between 7-nitro-1H-indole and ethyl chloroacetate in the presence of a base such as triethylamine. The reaction yields a high selectivity and good yield, making it a common method in organic synthesis.

Ethyl 7-nitro-1H-indole-2-carboxylate (CAS: 6960-46-9) is primarily used in the pharmaceutical industry for the synthesis of various indole-based drugs. It is also utilized in the development of sensors and semiconductors due to its unique chemical properties and the ease of functionalization.

When handling Ethyl 7-nitro-1H-indole-2-carboxylate (CAS: 6960-46-9), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Handling should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate cleaning agents. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures.