Ethyl 5-chloro-4-nitrothiophene-2-carboxylate(CAS: 89640-03-9)

Ethyl 5-chloro-4-nitrothiophene-2-carboxylate (CAS: 89640-03-9) is a crystalline compound with a molecular weight of approximately 250.03 g/mol. It has a low solubility in water but is moderately soluble in common organic solvents like ethanol and acetone. Chemically, it is reactive due to its thiophene and carboxylic acid functionalities, and it can undergo substitution and oxidation reactions easily.

Ethyl 5-chloro-4-nitrothiophene-2-carboxylate is typically synthesized from 5-chloro-4-nitrothiophene and ethyl chloroformate using triethylamine as a base. The reaction is carried out in an organic solvent like dichloromethane under stirring and cooling. The yield is usually around 70-80%, and the product can be purified by recrystallization.

Ethyl 5-chloro-4-nitrothiophene-2-carboxylate is used in the pharmaceutical industry for the synthesis of certain drugs, as well as in the development of sensors and electronic materials. Its reactivity and functional groups make it valuable for applications in polymer chemistry and semiconductor technology.

When handling Ethyl 5-chloro-4-nitrothiophene-2-carboxylate (CAS: 89640-03-9), ensure use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be neutralized with an appropriate reagent and cleaned up promptly. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures.