2-(3-fluorophenyl)-N-hydroxyethanimidamide(CAS: 872362-02-2)

2-(3-fluorophenyl)-N-hydroxyethanimidamide is a crystalline solid with a molecular weight of approximately 223.16 g/mol. It has a low solubility in water but is soluble in organic solvents. The compound exhibits moderate reactivity, particularly towards nucleophiles. It is stable under normal conditions but should be stored away from moisture and heat.

2-(3-fluorophenyl)-N-hydroxyethanimidamide is synthesized through a multi-step process involving the condensation of 3-fluorophenylamine with a suitable carboxylic acid chloride in the presence of a catalytic amount of a base. Common conditions include the use of triethylamine and dichloromethane as the solvent, yielding a high purity product with a good to excellent yield.

2-(3-fluorophenyl)-N-hydroxyethanimidamide finds applications in the pharmaceutical industry as a precursor for drug synthesis. It is also utilized in the polymer industry for the development of novel materials with specific properties. Additionally, it has potential uses in the production of sensors and semiconductors due to its chemical reactivity and functional groups.

When handling 2-(3-fluorophenyl)-N-hydroxyethanimidamide, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risk. Spills should be cleaned up with caution, using appropriate absorbent materials, and the area should be thoroughly rinsed. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.