4-(1,3-Oxazol-5-yl)benzonitrile(CAS: 87150-13-8)

4-(1,3-Oxazol-5-yl)benzonitrile (CAS: 87150-13-8) is a white crystalline solid with a molecular weight of approximately 198.16 g/mol. It is slightly soluble in water but miscible with organic solvents like ethanol and chloroform. Chemically, it is relatively stable but can react with strong bases and reducing agents. It has a melting point of 120-122°C and is used in various applications due to its physical and chemical properties.

4-(1,3-Oxazol-5-yl)benzonitrile (CAS: 87150-13-8) is typically synthesized via the condensation of 5-bromo-1,3-oxazole and benzonitrile in the presence of a base such as potassium carbonate or sodium hydroxide. The reaction is performed in an organic solvent like dimethylformamide (DMF) at elevated temperatures. The process yields a product with a yield of around 80-85%, and the reaction is monitored by thin-layer chromatography (TLC).

4-(1,3-Oxazol-5-yl)benzonitrile (CAS: 87150-13-8) is primarily used in the pharmaceutical industry for its potential in drug synthesis and as a building block for medicinal chemistry. It also finds applications in the polymer industry for the development of new materials and in the semiconductor industry for the fabrication of electronic devices. Additionally, it is used in sensor technology for detecting specific chemicals and in research for various analytical purposes.

When handling 4-(1,3-Oxazol-5-yl)benzonitrile (CAS: 87150-13-8), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The substance should be stored in a cool, dry place away from direct sunlight and flammable materials. Reactions involving this compound should be conducted in a well-ventilated hood or fume cupboard to minimize exposure to fumes. In case of a spill, it should be immediately cleaned up using appropriate absorbent materials, and the area should be thoroughly washed with water. The Safety Data Sheet (SDS) provides detailed information on handling and storage procedures, and it is essential to consult this document before working with the compound.