2-Methoxy-6-(trifluoromethyl)-4(1H)-pyrimidinone(CAS: 175354-56-0)

2-Methoxy-6-(trifluoromethyl)-4(1H)-pyrimidinone is a white crystalline solid. Its molecular weight is approximately 252.09 g/mol. It has low solubility in water but is soluble in organic solvents like methanol and acetonitrile. The compound is relatively stable but can react with bases to form pyrimidine derivatives. It is commonly used in organic synthesis and pharmaceuticals due to its reactivity and stability.

2-Methoxy-6-(trifluoromethyl)-4(1H)-pyrimidinone is typically synthesized by the reaction of 6-chloro-4(1H)-pyrimidinone with methoxy trifluoromethyl sulfonyl chloride in the presence of a base such as triethylamine. The reaction is carried out in an inert solvent like dichloromethane or tetrahydrofuran. The yield is around 85%, and the reaction is selective and efficient.

2-Methoxy-6-(trifluoromethyl)-4(1H)-pyrimidinone is used in various industries, including pharmaceuticals, where it serves as a precursor for the synthesis of antiviral and antifungal drugs. It is also utilized in the polymer industry for its chemical reactivity and stability in organic media. Additionally, it finds applications in the production of sensors and semiconductors.

When handling 2-Methoxy-6-(trifluoromethyl)-4(1H)-pyrimidinone, it is important to use appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Ensure the use of a fume hood to minimize inhalation risks. Handle the compound in a well-ventilated area to avoid exposure. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be ventilated thoroughly. Refer to the safety data sheet (SDS) for detailed handling and disposal instructions.