(5-Acetyl-2-fluorophenyl)boronic acid(CAS: 870777-29-0)

(5-Acetyl-2-fluorophenyl)boronic acid (CAS: 870777-29-0) is a crystalline solid with a molecular weight of approximately 222.08 g/mol. It has a melting point of 118-120°C and is slightly soluble in water. This compound is known for its reactivity, particularly in esterification and ester exchange reactions. It is also used in various organic synthesis applications due to its electrophilic nature.

(5-Acetyl-2-fluorophenyl)boronic acid (CAS: 870777-29-0) can be synthesized via a multistep process involving the protection of a phenol with acetyl chloride, followed by a boronic acid formation step using a boronate ester. Common catalysts include palladium(II) acetate, and the reaction typically yields 80-90% purity. This compound is often used in intermediate steps for drug synthesis and other organic transformations.

(5-Acetyl-2-fluorophenyl)boronic acid (CAS: 870777-29-0) is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of drug molecules and certain polymers. Its use in sensor technology and semiconductor fabrication is also growing, due to its specific reactivity and functionality.

When handling (5-Acetyl-2-fluorophenyl)boronic acid (CAS: 870777-29-0), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a fume hood to minimize inhalation risk. Spills should be handled with care using appropriate absorbent materials, and the area should be ventilated. Always consult the Safety Data Sheet (SDS) for specific handling and emergency procedures.