Dimethyl (3-fluoro-2-nitrophenyl)malonate(CAS: 872141-24-7)

Dimethyl (3-fluoro-2-nitrophenyl)malonate is a crystalline solid with a molecular weight of approximately 297.05 g/mol. It is slightly soluble in water but has good solubility in organic solvents like ethanol and acetone. Chemically, it is highly reactive, particularly towards nucleophiles and reducing agents. Its physical properties include a melting point of 75-77°C and a density around 1.32 g/cm³.

Dimethyl (3-fluoro-2-nitrophenyl)malonate is typically synthesized via the esterification of 3-fluoro-2-nitrophenyl malonic acid with dimethyl carbonate in the presence of a catalyst like triethylamine. The reaction is performed under mild conditions, leading to a yield of about 85-90%. The process is selective and environmentally friendly, making it a preferred method for industrial synthesis.

Dimethyl (3-fluoro-2-nitrophenyl)malonate finds applications in the pharmaceutical industry for drug synthesis, particularly in the development of antibacterial and antiviral compounds. It is also utilized in the production of polymers for specialty applications and as a precursor in the development of advanced sensors and semiconductors.

When handling Dimethyl (3-fluoro-2-nitrophenyl)malonate, it is crucial to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or a fume hood to prevent inhalation. In case of spills, immediately clean up with appropriate absorbent materials and consult the Safety Data Sheet (SDS) for further instructions. Always store the compound in a cool, dry place away from heat and ignition sources.