[2-Amino-4-(methoxycarbonyl)phenyl]boronic acid hydrochloride (1:1)(CAS: 380430-55-7)

This compound is a crystalline solid with a molecular weight of approximately 313.5 g/mol. It has a solubility of about 1.5 g/L in water. Chemically, it is reactive towards nucleophiles and forms stable complexes with metal ions. It is hydrolytically stable but should be stored below 30°C to prevent degradation.

It is synthesized via a multi-step process involving the protection of an amine group, subsequent esterification, and finally the formation of the boronic acid derivative. Commonly used catalysts include palladium(II) acetate and triphenylphosphine. The yield is typically around 85-90%. This method ensures high selectivity and good purity.

This compound is used in the pharmaceutical industry for the synthesis of drug molecules, particularly those involving boronate esters. It is also utilized in polymer chemistry for the modification of boronic acid functionalities, and in the semiconductor industry for the production of advanced materials with specific optical and electronic properties.

When handling this compound, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure that all work is done in a well-ventilated fume hood to avoid inhalation of dust. Spills should be handled using absorbent materials and carefully disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information.