N-(2-Methoxyphenyl)acetamide

Basic Information

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CAS Number

93-26-5

Molecular Formula

C9H11NO2

Molecular Weight

165.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Powder

Melting Point

85.0 to 89.0 deg-C

Boiling Point

303-305 °C

Density

1.1603 (rough estimate)

Flash Point

138

Refractive Index

1.5839 (estimate)

SMILES

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CC(=O)NC1=CC=CC=C1OC

InChI

InChI=1S/C9H11NO2/c1-7(11)10-8-5-3-4-6-9(8)12-2/h3-6H,1-2H3,(H,10,11)

InChIKey

FGOFNVXHDGQVBG-UHFFFAOYSA-N

LogP

1.6535999999999997

Topological Polar Surface Area

38.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

159

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

N-(2-Methoxyphenyl)acetamide
o-Acetanisidide
o-Methoxyacetanilide
o-Acetanisidine
2-Methoxyacetanilide
2'-Methoxyacetanilide
Acetamide, N-(2-methoxyphenyl)-
Acetanilide, 2'-methoxy-
Acetyl-O-anisidine
N-Acetyl-o-anisidine
2-ACETAMIDOANISOLE
Acetamide, N-(methoxyphenyl)-
N-ACETYL-ORTHO-ANISIDINE
FGOFNVXHDGQVBG-UHFFFAOYSA-N
N-(2-METHOXYPHENYL) ACETAMIDE
Q63392790
Aceto-o-anisidine
NSC4004
PubChem3319
N-acetyl-2-anisidine
2-(Acetyla
N-(2-Methoxyphenyl)acetamide (ACI)
o-Acetanisidide (6CI, 7CI, 8CI)
2-(Acetylamino)anisole
2-Acetamidoanisole
2-N-Acetylaminomethoxybenzene
2′-Methoxyacetanilide
N-Acetyl-2-methoxyaniline
NSC 4004
NSC-4004
SDCCGMLS-0033745.P002

MDL Number

MFCD00026117

Customs Code

2924299090

FAQ

What are the physical and chemical properties of N-(2-Methoxyphenyl)acetamide (CAS: 93-26-5)?

N-(2-Methoxyphenyl)acetamide (CAS: 93-26-5) is a colorless solid with a crystalline form. It has a molecular weight of approximately 174.24 g/mol. The compound is slightly soluble in water but soluble in organic solvents such as ethanol and acetone. It is relatively stable under normal conditions but can react with strong bases to form acetamides. The compound has a moderate reactivity with nucleophiles and can undergo substitution reactions in the presence of a base.

How is N-(2-Methoxyphenyl)acetamide (CAS: 93-26-5) typically synthesized?

N-(2-Methoxyphenyl)acetamide (CAS: 93-26-5) is typically synthesized by reacting acetamide with 2-methoxybenzoyl chloride in the presence of a base such as triethylamine. The reaction is carried out in a suitable organic solvent like dichloromethane. The yield is usually around 70-80%, and the method is highly selective and efficient for producing this compound.

What industries use N-(2-Methoxyphenyl)acetamide (CAS: 93-26-5)?

N-(2-Methoxyphenyl)acetamide (CAS: 93-26-5) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various organic compounds. It is also utilized in the polymer industry for functionalizing polymers to improve their properties. Additionally, it has applications in the sensor and semiconductor industries due to its chemical reactivity and stability.

What precautions should be taken when handling N-(2-Methoxyphenyl)acetamide (CAS: 93-26-5)?

When handling N-(2-Methoxyphenyl)acetamide (CAS: 93-26-5), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation of vapors. Spills should be cleaned up using appropriate absorbent materials, and proper disposal methods should be followed. Always refer to the safety data sheet (SDS) for detailed guidance on handling and storage.