Methyl 3-chloro-2-hydroxybenzoate(CAS: 52159-67-8)

Methyl 3-chloro-2-hydroxybenzoate has a crystalline form with a molecular weight of approximately 219.58 g/mol. It is slightly soluble in water and has good solubility in common organic solvents like ethanol and acetone. The compound is moderately reactive, particularly with reagents that can introduce nucleophilic substitution or oxidation reactions.

Methyl 3-chloro-2-hydroxybenzoate is typically synthesized via the esterification of 3-chloro-2-hydroxybenzoic acid with methanol in the presence of an acid catalyst such as sulfuric acid. The process involves heating the reaction mixture under reflux to achieve a high yield of the desired ester.

Methyl 3-chloro-2-hydroxybenzoate is used in various industries, including pharmaceuticals, where it serves as a precursor for the synthesis of certain drugs. It is also used in the production of organic pigments and dyes, as a raw material in the chemical industry, and in the formulation of certain consumer products.

When handling Methyl 3-chloro-2-hydroxybenzoate, it is crucial to wear appropriate personal protective equipment, including gloves, goggles, and a lab coat. The compound should be stored in a dry, well-ventilated area, away from direct sunlight and heat sources. Spills should be cleaned up using appropriate chemical spill kits, and the area should be well-ventilated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.