Ethyl 2,6-dichloronicotinate(CAS: 58584-86-4)

Ethyl 2,6-dichloronicotinate (CAS: 58584-86-4) is a crystalline solid with a molecular weight of approximately 237.06 g/mol. It has a low solubility in water (0.1 g/100 mL at 20°C) but is more soluble in organic solvents like methanol and ethanol. This compound is reactive and can undergo hydrolysis under basic conditions. It is stable under normal storage conditions but should be kept away from strong acids and bases to prevent unwanted reactions.

Ethyl 2,6-dichloronicotinate (CAS: 58584-86-4) can be synthesized via the reaction of 2,6-dichloronicotinic acid with ethylamine in the presence of a base like sodium hydroxide. The process involves heating the mixture to promote the nucleophilic substitution reaction, followed by acidification to isolate the product. High selectivity and yield can be achieved with proper temperature and concentration control.

Ethyl 2,6-dichloronicotinate (CAS: 58584-86-4) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the chemical industry for the production of dyes and pigments. Additionally, it can be used in the research and development of new materials, particularly in the fabrication of sensors and semiconductors.

When handling Ethyl 2,6-dichloronicotinate (CAS: 58584-86-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be carefully cleaned up using appropriate absorbent materials and flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions and follow all local safety regulations.