(4-Chloro-3-methoxyphenyl)boronic acid(CAS: 89694-47-3)

(4-Chloro-3-methoxyphenyl)boronic acid is a white crystalline solid with a molecular weight of approximately 228.04 g/mol. It is slightly soluble in water and ethanol. This compound displays good reactivity in boronate ester formation and is used as a boronic acid building block in organic synthesis. Its solubility and reactivity make it a valuable reagent in various chemical processes.

(4-Chloro-3-methoxyphenyl)boronic acid is commonly synthesized through the coupling of 4-chloro-3-methoxybenzene with boron tribromide in a solvent like toluene. The reaction is generally carried out in the presence of a base such as sodium hydroxide to promote boronation. The yield and selectivity of the synthesis can be enhanced by optimizing reaction conditions and using appropriate catalysts.

(4-Chloro-3-methoxyphenyl)boronic acid is primarily used in the pharmaceutical industry for the synthesis of new drugs and intermediates. It is also utilized in the polymer industry for the development of advanced materials. Additionally, this compound can be applied in sensor technology and semiconductor manufacturing due to its unique chemical properties.

Handling (4-Chloro-3-methoxyphenyl)boronic acid should be done with appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Ensure that all operations are conducted in a fume hood to minimize exposure to fumes. Spills should be carefully cleaned up using absorbent materials and appropriate waste handling procedures as per the safety data sheet (SDS). Always refer to the latest SDS for specific safety guidelines and emergency procedures.