3-(Trifluoromethyl)dibenzo[b,e]oxepin-11(6H)-one(CAS: 4504-94-3)

3-(Trifluoromethyl)dibenzo[b,e]oxepin-11(6H)-one is a white crystalline solid with a molecular weight of approximately 341.15 g/mol. It has limited water solubility but is more soluble in organic solvents like DMSO and DMF. The compound is known for its stability under normal conditions but requires careful handling due to its reactivity with certain reagents.

3-(Trifluoromethyl)dibenzo[b,e]oxepin-11(6H)-one can be synthesized via a multistep reaction involving the condensation of 3-(trifluoromethyl)acrylic acid and vicinal ketals, followed by ring closure and subsequent dehydration. This process often requires the use of Lewis acids as catalysts and typically yields up to 80% purity.

3-(Trifluoromethyl)dibenzo[b,e]oxepin-11(6H)-one finds applications in the pharmaceutical industry for its potential as a precursor in the synthesis of bioactive compounds. It is also utilized in the polymer industry for its unique chemical properties and in the sensor industry for its reactivity with certain analytes.

When handling 3-(Trifluoromethyl)dibenzo[b,e]oxepin-11(6H)-one, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbents, and the area should be thoroughly washed down. Always consult the Safety Data Sheet (SDS) for detailed safety guidelines.