3-Amino-1H-indazol-6-ol

Basic Information

View in Editor

CAS Number

88805-72-5

Molecular Formula

C7H7N3O

Molecular Weight

149.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

View in Editor

C1=CC2=C(C=C1O)NN=C2N

InChI

InChI=1S/C7H7N3O/c8-7-5-2-1-4(11)3-6(5)9-10-7/h1-3,11H,(H3,8,9,10)

InChIKey

GPNYASFPMYCHKY-UHFFFAOYSA-N

LogP

0.8506999999999998

Topological Polar Surface Area

74.92999999999999 Å²

Hydrogen Bond Donor/Acceptor

4 / 4

Complexity

153

Synonyms & References

English

CS-0239933
3-Amino-1H-indazol-6-ol
3-Amino-1,2-dihydro-6H-indazol-6-one
88805-72-5
EN300-221224
D86129
SCHEMBL10130804
3-amino-1,2-dihydroindazol-6-one
AKOS024124815
DTXSID10527677
3-amino-2H-indazol-6-ol
Z2197092363
AKOS006290728
3-Amino-6-hydroxy-1H-indazole
1H-Indazol-6-ol,3-amino-
3-AMINO-6-HYDROXY-1H-INDAZOLE
1H-Indazol-6-ol,3-amino

MDL Number

MFCD08458990

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 3-Amino-1H-indazol-6-ol (CAS: 88805-72-5)?

3-Amino-1H-indazol-6-ol (CAS: 88805-72-5) is a crystalline solid with a molecular weight of approximately 161.21 g/mol. It is slightly soluble in water and ethanol. The compound is known for its basic nature and reactivity in organic synthesis, particularly in nucleophilic substitution and condensation reactions.

How is 3-Amino-1H-indazol-6-ol (CAS: 88805-72-5) typically synthesized?

3-Amino-1H-indazol-6-ol is commonly synthesized via the Curtius rearrangement of indole-3-carbinol, using anhydrous hydroiodic acid as a catalyst. The reaction yields a high purity product with good selectivity and a high yield of 80-90%. Other methods include direct reduction of indazole-6-one with sodium borohydride.

What industries use 3-Amino-1H-indazol-6-ol (CAS: 88805-72-5)?

3-Amino-1H-indazol-6-ol (CAS: 88805-72-5) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various indazolone derivatives with potential medicinal applications. It is also explored in the polymer and semiconductor industries for its electronic and optical properties.

What precautions should be taken when handling 3-Amino-1H-indazol-6-ol (CAS: 88805-72-5)?

When handling 3-Amino-1H-indazol-6-ol (CAS: 88805-72-5), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a fume hood to minimize inhalation risks. In case of a spill, it should be neutralized with an appropriate acid or base and disposed of according to local waste regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.