1-(5-Methoxy-1H-indol-3-yl)methanamine

Basic Information

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CAS Number

60523-82-2

Molecular Formula

C10H12N2O

Molecular Weight

176.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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COc1ccc2[nH]cc(CN)c2c1

InChI

InChI=1S/C10H12N2O/c1-13-8-2-3-10-9(4-8)7(5-11)6-12-10/h2-4,6,12H,5,11H2,1H3

InChIKey

CAHOMULUOHSWPI-UHFFFAOYSA-N

LogP

1.6352

Topological Polar Surface Area

51.04 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Synonyms & References

English

3-(aminomethyl)-5-methoxyindole
(5-Methoxy-1H-indol-3-yl)methanamine
[(5-Methoxy-1H-indol-3-yl)methyl]amine hydrochloride

MDL Number

MFCD06657119

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1-(5-Methoxy-1H-indol-3-yl)methanamine (CAS: 60523-82-2)?

1-(5-Methoxy-1H-indol-3-yl)methanamine (CAS: 60523-82-2) is a white crystalline solid. It has a molecular weight of approximately 219.24 g/mol. This compound is soluble in organic solvents such as methanol and dimethylformamide. It is mildly alkaline and reactive towards acidic compounds. It exhibits basic properties and can form salts with acids.

How is 1-(5-Methoxy-1H-indol-3-yl)methanamine (CAS: 60523-82-2) typically synthesized?

1-(5-Methoxy-1H-indol-3-yl)methanamine is typically synthesized through a multi-step process involving the synthesis of 5-methoxyindole followed by methylation. The key steps include the reaction of indole with methanol in the presence of a base to form 5-methoxyindole, which is then reacted with methylamine to yield the final product. The yield is around 70-80%, and the purity is typically 95% or higher.

What industries use 1-(5-Methoxy-1H-indol-3-yl)methanamine (CAS: 60523-82-2)?

1-(5-Methoxy-1H-indol-3-yl)methanamine (CAS: 60523-82-2) is primarily used in the pharmaceutical industry as a precursor for drug development. It is also explored in the polymer industry for its potential use in the synthesis of novel polymers. Additionally, it has applications in the development of sensor materials and as a precursor in semiconductor manufacturing processes.

What precautions should be taken when handling 1-(5-Methoxy-1H-indol-3-yl)methanamine (CAS: 60523-82-2)?

When handling 1-(5-Methoxy-1H-indol-3-yl)methanamine (CAS: 60523-82-2), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using absorbent material and the area should be flushed with water. Always refer to the safety data sheet (SDS) for detailed instructions on handling and storage. This compound is mildly reactive and may require special storage conditions to prevent degradation.