Sotalol Hydrochloride(CAS: 959-24-0)

Sotalol Hydrochloride (CAS: 959-24-0) is a white or almost white crystalline powder. Its molecular weight is approximately 299.77 g/mol. It is sparingly soluble in water but soluble in ethanol. Chemically, it is a beta-adrenergic antagonist and antiarrhythmic agent. It is stable under normal conditions but may react with strong bases to form sotalol. It has a melting point of around 140-150°C.

Sotalol Hydrochloride is typically synthesized by the alkylation of 1,3-bis(chloromethyl)-5-methyl-2-phenyl-1H-indole with 2-methyl-2-(trifluoromethyl)propan-1-ol, followed by hydrolysis and acidification to produce the hydrochloride salt. Commonly used catalysts include triphenylphosphine and triethylamine. The yield is typically around 85-90%.

Sotalol Hydrochloride (CAS: 959-24-0) is primarily used in the pharmaceutical industry as a beta-adrenergic antagonist and antiarrhythmic agent. It is also used in some sensor applications for its electroactive properties. While not extensively used in other industries, it can be found in specialized polymer and semiconductor applications.

When handling Sotalol Hydrochloride (CAS: 959-24-0), appropriate personal protective equipment (PPE) such as laboratory coats, gloves, and safety goggles should be worn. It should be stored in a cool, dry place away from strong acids and bases. In case of a spill, it should be contained and disposed of according to the Material Safety Data Sheet (MSDS) guidelines. It is recommended to work in a fume hood to avoid inhalation. Always refer to the latest safety data sheet for detailed information.