2,4,6-Trichloronicotinaldehyde(CAS: 1261269-66-2)

2,4,6-Trichloronicotinaldehyde is a white crystalline solid with a molecular weight of approximately 217.07 g/mol. It has low water solubility and is moderately soluble in organic solvents. This compound is known for its reactivity with nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from moisture and reducing agents.

2,4,6-Trichloronicotinaldehyde is typically synthesized by chlorinating nicotinaldehyde using thionyl chloride as the chlorinating agent. The reaction is conducted in a polar aprotic solvent, and the product is isolated by recrystallization. This method provides good yield and selectivity, making it a common approach for preparing this compound in the laboratory.

2,4,6-Trichloronicotinaldehyde is used in the pharmaceutical industry for the synthesis of various intermediates and drugs. It also finds applications in the polymer industry as a crosslinking agent and in the development of sensors and semiconductors due to its unique chemical properties.

Proper personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat should be worn when handling 2,4,6-Trichloronicotinaldehyde. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. If a spill occurs, it should be contained and handled according to the Material Safety Data Sheet (MSDS) guidelines. Storage should be in a cool, dry place, away from reducing agents and moisture. Always refer to the latest MSDS for detailed safety information.