(5alpha,17beta)-17-Hydroxyandrostan-3-one(CAS: 521-18-6)

(5alpha,17beta)-17-Hydroxyandrostan-3-one is a white crystalline powder with a molecular weight of approximately 282.43 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and ethanol. This compound is known for its low reactivity under normal conditions but can undergo hydrolysis in the presence of strong acids or bases. It is commonly used in research and pharmaceutical applications due to its hormonal properties.

(5alpha,17beta)-17-Hydroxyandrostan-3-one is typically synthesized through a series of reactions starting from androst-4-ene. A common method involves the reduction of androst-4-ene to androstan-4-ol, followed by a keto-reduction to form the final product. This synthesis often employs lithium aluminum hydride (LAH) as a reducing agent, with careful control of reaction conditions to ensure high yield and selectivity.

(5alpha,17beta)-17-Hydroxyandrostan-3-one is primarily used in the pharmaceutical industry for hormone-related research and development. It is also utilized in the production of certain steroid and hormonal drugs. Additionally, this compound may have applications in the field of chemical sensors and as a reagent in organic synthesis.

When handling (5alpha,17beta)-17-Hydroxyandrostan-3-one, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coats. Ensure the work is conducted in a well-ventilated area or under a fume hood. Spills should be cleaned up immediately, and care should be taken to avoid skin and eye contact. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.