Methyl 3-[(trifluoroacetyl)amino]-2-thiophenecarboxylate(CAS: 79128-68-0)

Methyl 3-[(trifluoroacetyl)amino]-2-thiophenecarboxylate is a crystalline solid with a molecular weight of approximately 337.08 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and dimethylformamide. The compound is known for its reactivity, particularly towards nucleophiles due to the presence of the trifluoroacetyl group.

Methyl 3-[(trifluoroacetyl)amino]-2-thiophenecarboxylate is synthesized through a multi-step process involving the protection of a thiophene ring with trifluoroacetic anhydride, followed by amino substitution. The reaction is catalyzed by a strong base like sodium hydride, and the overall yield is around 75%.

Methyl 3-[(trifluoroacetyl)amino]-2-thiophenecarboxylate finds applications in the pharmaceutical industry for the synthesis of certain drugs. It is also used in the development of sensors and semiconductors due to its unique chemical properties.

When handling Methyl 3-[(trifluoroacetyl)amino]-2-thiophenecarboxylate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work must be conducted in a well-ventilated area or a fume hood to avoid inhalation. In case of spills, immediately clean up using appropriate absorbents and follow safety data sheet (SDS) guidelines for disposal.