Dimethyl (2-methoxyphenoxy)malonate(CAS: 150726-89-9)

Dimethyl (2-methoxyphenoxy)malonate is a colorless to light yellow liquid. It has a molecular weight of approximately 198.22 g/mol and a density of 1.09 g/cm³. The compound is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. It is moderately reactive and can undergo ester hydrolysis, making it susceptible to base-catalyzed breakdown.

Dimethyl (2-methoxyphenoxy)malonate can be synthesized via esterification of 2-methoxyphenoxyacetic acid with dimethyl malonate. The reaction is typically catalyzed by an acid like sulfuric acid. The process involves heating the reactants under reflux to achieve a yield of about 75-85%, with selectivity towards the desired ester product.

Dimethyl (2-methoxyphenoxy)malonate is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly in the production of certain active pharmaceutical ingredients (APIs). It also finds application in the development of novel polymers and in the field of organic semiconductors for electronic devices.

When handling Dimethyl (2-methoxyphenoxy)malonate, proper personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. The compound should be stored in a cool, well-ventilated area away from heat sources and incompatible materials. Spills should be cleaned up using appropriate absorbent materials and disposal should follow local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage information.