Methyl 5-hydroxynicotinate(CAS: 30766-22-4)

Methyl 5-hydroxynicotinate (CAS: 30766-22-4) is a white crystalline solid with a molecular weight of approximately 165.21 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards bases and oxidizing agents. It decomposes above 150°C and is unstable in acidic conditions.

Methyl 5-hydroxynicotinate is commonly synthesized by the hydroxylation of nicotinic acid followed by esterification with methyl alcohol. The reaction typically uses a hydrogenation catalyst like platinum or palladium on charcoal. The yield can be enhanced by optimizing the reaction conditions such as temperature, pressure, and the use of appropriate solvents.

Methyl 5-hydroxynicotinate (CAS: 30766-22-4) is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It also finds application in the synthesis of pesticides and as a chemical reagent in analytical chemistry for spectroscopic studies and as a probe in biological assays.

When handling Methyl 5-hydroxynicotinate (CAS: 30766-22-4), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The substance should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents. Detailed safety data sheets (SDS) should be consulted for comprehensive safety information.