Diethyl {[3-(bromomethyl)-2-thienyl]methylene}malonate(CAS: 104085-30-5)

Diethyl {[3-(bromomethyl)-2-thienyl]methylene}malonate (CAS: 104085-30-5) is a crystalline compound with a molecular weight of around 342.14 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and acetone. It is moderately reactive and can undergo nucleophilic substitution reactions. The compound is stable under normal conditions but should be stored in a dry, cool place.

Diethyl {[3-(bromomethyl)-2-thienyl]methylene}malonate can be synthesized through a multi-step process involving bromination and malonate esterification. Commonly, 2-bromothiophene and malonic acid diethyl ester are reacted in the presence of a base like triethylamine to form the desired product. The yield is typically around 70-80%, with good selectivity for the targeted esterification step.

Diethyl {[3-(bromomethyl)-2-thienyl]methylene}malonate (CAS: 104085-30-5) is used in the pharmaceutical industry for intermediate synthesis and in the polymer industry for functional polymer modifications. It can also be utilized in sensor technology and semiconductor manufacturing for specific chemical functionalities.

When handling Diethyl {[3-(bromomethyl)-2-thienyl]methylene}malonate (CAS: 104085-30-5), it is important to use appropriate personal protective equipment (PPE) such as lab coats, gloves, and safety goggles. Work should be conducted in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up using absorbent materials and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.