Compound Q&A
How is Diethyl {[3-(bromomethyl)-2-thienyl]methylene}malonate (CAS: 104085-30-5) typically synthesized?
Answer
![Diethyl {[3-(bromomethyl)-2-thienyl]methylene}malonate](https://static.chemtradehub.com/structs/104/104085-30-5-9a94.webp "Diethyl {[3-(bromomethyl)-2-thienyl]methylene}malonate")
Diethyl {[3-(bromomethyl)-2-thienyl]methylene}malonate can be synthesized through a multi-step process involving bromination and malonate esterification. Commonly, 2-bromothiophene and malonic acid diethyl ester are reacted in the presence of a base like triethylamine to form the desired product. The yield is typically around 70-80%, with good selectivity for the targeted esterification step.
About
CAS No
104085-30-5
English Name
Diethyl {[3-(bromomethyl)-2-thienyl]methylene}malonate
Molecular Formula
C13H15BrO4S
Molecular Weight
347.23 g/mol
SMILES
CCOC(=O)C(=CC1=C(C=CS1)CBr)C(=O)OCC
InChIKey
ADBJZPBDGYLFRT-UHFFFAOYSA-N
Last Updated: 2026-03-07 15:41
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