Fmoc-Val-Cit-PAB-MMAE(CAS: 1350456-56-2)

Fmoc-Val-Cit-PAB-MMAE (CAS: 1350456-56-2) is a crystalline compound with a molecular weight of approximately 738.7 g/mol. It has a low solubility in water but is soluble in organic solvents like DMSO and DMF. The compound is reactive towards nucleophiles and can undergo amidation reactions. It is stable under neutral and mildly acidic conditions but should be stored in dry conditions to avoid degradation.

Fmoc-Val-Cit-PAB-MMAE (CAS: 1350456-56-2) is synthesized by coupling Fmoc-Val-Cit-PAB with MMAE (MMAE is a macromer derivative) using standard peptide coupling chemistry. The reaction typically involves activating the amino group of Val-Cit-PAB with Fmoc protection, followed by deprotection and coupling with MMAE. The process requires careful control of pH and temperature to ensure high yield and selectivity.

Fmoc-Val-Cit-PAB-MMAE (CAS: 1350456-56-2) is primarily used in the pharmaceutical industry for conjugation of antibodies and proteins. It is also utilized in the polymer industry for preparing functional polymers with specific properties. Additionally, it is applied in the semiconductor and sensor industries for creating functionalized devices and materials with enhanced performance.

When handling Fmoc-Val-Cit-PAB-MMAE (CAS: 1350456-56-2), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The compound should be stored in a cool, dry place away from direct sunlight. Spills should be cleaned up immediately using appropriate absorbents. Always consult the safety data sheet (SDS) for detailed information on handling and disposal. Fume hood use is recommended during handling to minimize inhalation exposure.