Compound Q&A
How is Fmoc-Val-Cit-PAB-MMAE (CAS: 1350456-56-2) typically synthesized?
Answer
Fmoc-Val-Cit-PAB-MMAE (CAS: 1350456-56-2) is synthesized by coupling Fmoc-Val-Cit-PAB with MMAE (MMAE is a macromer derivative) using standard peptide coupling chemistry. The reaction typically involves activating the amino group of Val-Cit-PAB with Fmoc protection, followed by deprotection and coupling with MMAE. The process requires careful control of pH and temperature to ensure high yield and selectivity.
About
CAS No
1350456-56-2
English Name
Fmoc-Val-Cit-PAB-MMAE
Molecular Formula
C73H104N10O14
Molecular Weight
1345.69 g/mol
SMILES
CC[C@@H]([C@H](N(C(=O)[C@H](C(C)C)NC(=O)[C@@H](N(C(=O)OCc1ccc(cc1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)OCC1c2ccccc2c2c1cccc2)CCCNC(=O)N)C)C(C)C)C)[C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@H](C(=O)N[C@@H]([C@H](c1ccccc1)O)C)C)OC)OC)C
InChIKey
RHQGFVOXIOMBMC-UUMMFNFXSA-N
Last Updated: 2025-11-04 22:31
