5-Chloro-2-methoxyisonicotinic acid(CAS: 88912-22-5)

5-Chloro-2-methoxyisonicotinic acid is a crystalline solid with a molecular weight of approximately 195.65 g/mol. It has a solubility of about 26 mg/L in water. Chemically, it is moderately reactive, particularly with bases which can lead to hydrolysis. It exhibits acidic behavior in aqueous solutions due to its carboxylic acid group.

5-Chloro-2-methoxyisonicotinic acid can be synthesized through the reaction of 2-methoxyisonicotinic chloride with sodium hydroxide. This process involves the substitution of a chlorine atom on the isonicotinic acid moiety, leading to a high yield of the desired product with good selectivity.

5-Chloro-2-methoxyisonicotinic acid finds applications in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the development of sensors and as an intermediate in the production of organic materials, particularly in the polymer industry.

When handling 5-Chloro-2-methoxyisonicotinic acid, it is important to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.