4-Bromo-1-chloroisoquinoline(CAS: 66728-98-1)

4-Bromo-1-chloroisoquinoline (CAS: 66728-98-1) is a crystalline solid with a molecular weight of approximately 261.04 g/mol. It has a low solubility in water but is more soluble in common organic solvents like dichloromethane and acetone. Chemically, it is relatively stable but can react with strong bases and acids. It has a characteristic melting point range of 140-142°C. It is used in various chemical processes and research due to its unique structural features.

4-Bromo-1-chloroisoquinoline (CAS: 66728-98-1) is typically synthesized via a multi-step process involving the bromination of 1-chloroisatin followed by a condensation reaction. The reaction is catalyzed by phosphorus oxychloride and proceeds with high selectivity, yielding a high percentage of the desired product. The process involves careful control of reaction conditions to ensure purity and yield.

4-Bromo-1-chloroisoquinoline (CAS: 66728-98-1) is primarily used in the pharmaceutical and chemical research industries. It serves as a key intermediate in the synthesis of various bioactive compounds and is also studied for its potential applications in organic electronics and materials science.

When handling 4-Bromo-1-chloroisoquinoline (CAS: 66728-98-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The substance should be handled in a well-ventilated area or under a fume hood due to its potential reactivity. Spills should be cleaned up promptly and reported to laboratory personnel. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.