1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarboxylic acid(CAS: 862574-88-7)

1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarboxylic acid is a crystalline compound with a molecular weight of approximately 281.14 g/mol. It has low water solubility and is soluble in organic solvents. This compound exhibits moderate reactivity, particularly in esterification and amidation reactions. It is stable under normal conditions but may degrade at high temperatures or in strong bases.

1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarboxylic acid is typically synthesized via a multi-step process involving the protection of a primary alcohol followed by ring closure, fluorination, and deprotection. Common synthetic methods include the use of protecting groups such as tert-butyldimethylsilyl (TBS) and fluorinated reagents like difluoromethyl sulfoxide (DMF-SO2). The overall yield can be around 50-70% depending on the reaction conditions and purification methods.

1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarboxylic acid is used in the pharmaceutical industry for the synthesis of pharmaceutical intermediates. It also finds applications in the polymer industry as a monomer and in the development of advanced materials. This compound is also utilized in the field of chemical sensors due to its specific reactivity and stability under various conditions.

When handling 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarboxylic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up according to standard laboratory procedures, and the material safety data sheet (MSDS) should be consulted for specific disposal instructions. This compound is stable under normal conditions but should be stored away from heat sources and strong bases.