L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-methylethyl ester(CAS: 261909-49-3)

N-(chlorophenoxyphosphinyl)-L-alanine, 1-methylethyl ester is a white crystalline solid with a molecular weight of approximately 364.07 g/mol. It is sparingly soluble in water but soluble in common organic solvents such as methanol and ethanol. The compound is reactive towards nucleophiles and can undergo phosphinylation reactions. It is stable under normal storage conditions but should be protected from strong bases and oxidizing agents.

N-(chlorophenoxyphosphinyl)-L-alanine, 1-methylethyl ester is typically synthesized through a multi-step process involving phosphinylation of L-alanine with chlorophenoxyphosphonic acid, followed by esterification with 1-methylethanol. The reaction is catalyzed by a Lewis acid and proceeds with good selectivity. The overall yield is around 85-90%, and the method is scalable for industrial production.

N-(chlorophenoxyphosphinyl)-L-alanine, 1-methylethyl ester is primarily used in the pharmaceutical industry for the synthesis of new drugs. It is also applied in the polymer industry to enhance material properties and in the sensor industry for developing advanced chemical sensors. Additionally, it has potential applications in the semiconductor industry due to its electronic properties.

When handling N-(chlorophenoxyphosphinyl)-L-alanine, 1-methylethyl ester, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat is essential. The compound should be handled in a well-ventilated area or a fume hood. Spills should be managed by professional chemical cleaning agents, and the area should be flushed with water. Refer to the Safety Data Sheet (SDS) for detailed emergency response procedures.