4,4,5,5-Tetramethyl-2-(5-methyl-2-thienyl)-1,3,2-dioxaborolane(CAS: 476004-80-5)

4,4,5,5-Tetramethyl-2-(5-methyl-2-thienyl)-1,3,2-dioxaborolane is a colorless, crystalline solid. It has a molecular weight of approximately 262.15 g/mol and a melting point of 62-64°C. The compound is soluble in organic solvents such as dichloromethane and toluene. It is less soluble in water. Chemically, it is reactive towards nucleophiles and can undergo various transformations such as substitution and addition reactions.

4,4,5,5-Tetramethyl-2-(5-methyl-2-thienyl)-1,3,2-dioxaborolane is typically synthesized via a multistep process involving the reaction of thiophene with methyl orthoformate in the presence of a catalyst such as tetrakis(triphenylphosphine)palladium(0). The overall reaction involves the formation of an intermediate, followed by dioxaborolane formation. The yield is generally high, and the method is highly selective.

4,4,5,5-Tetramethyl-2-(5-methyl-2-thienyl)-1,3,2-dioxaborolane is used in the pharmaceutical industry for the synthesis of medicinal compounds, particularly in the development of nucleoside analogs. It is also used in the polymer industry as a monomer and in the semiconductor industry for the production of organic semiconductors. Additionally, it finds applications in the development of sensors and other advanced materials.

When handling 4,4,5,5-Tetramethyl-2-(5-methyl-2-thienyl)-1,3,2-dioxaborolane, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Ensure the use of a fume hood to avoid inhalation risk. Spills should be cleaned up using appropriate absorbent materials and disposing of residues in accordance with local regulations. Refer to the safety data sheet (SDS) for detailed handling and emergency procedures.