Ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate(CAS: 101987-86-4)

Ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate (CAS: 101987-86-4) is a colorless to white crystalline solid with a molecular weight of approximately 321.02 g/mol. It has low water solubility and is soluble in organic solvents like acetone and dichloromethane. It is moderately reactive, particularly towards nucleophiles and bases. This compound is stable under normal conditions but should be stored in a tightly sealed container to prevent exposure to moisture and light.

Ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate (CAS: 101987-86-4) is synthesized from 3-chloro-2,4,5-trifluorophenol and acetyl chloride in the presence of a catalytic amount of aluminum chloride. The reaction involves acylation of the phenol, followed by esterification with ethyl alcohol. Common solvents include dichloromethane. The yield is typically around 70%, with good selectivity for the desired product.

Ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate (CAS: 101987-86-4) is used in the pharmaceutical industry for intermediate applications and in the synthesis of certain active pharmaceutical ingredients (APIs). It also has potential applications in the polymer industry, particularly in the development of fluorinated polymers with unique properties. Additionally, it can be used in chemical sensing technologies due to its reactivity.

When handling Ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate (CAS: 101987-86-4), it is important to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be handled by carefully collecting the material and disposing of it according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed information on handling and disposal procedures.