Compound Q&A
How is Ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate (CAS: 101987-86-4) typically synthesized?
Answer
Ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate (CAS: 101987-86-4) is synthesized from 3-chloro-2,4,5-trifluorophenol and acetyl chloride in the presence of a catalytic amount of aluminum chloride. The reaction involves acylation of the phenol, followed by esterification with ethyl alcohol. Common solvents include dichloromethane. The yield is typically around 70%, with good selectivity for the desired product.
About
CAS No
101987-86-4
English Name
Ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate
Molecular Formula
C11H8ClF3O3
Molecular Weight
280.63 g/mol
SMILES
CCOC(=O)CC(=O)C1=CC(=C(C(=C1F)Cl)F)F
InChIKey
LZMXLCPYJNRWNQ-UHFFFAOYSA-N
Last Updated: 2025-09-26 00:09
