(1-Chloro-4-isoquinolinyl)boronic acid(CAS: 848841-48-5)

(1-Chloro-4-isoquinolinyl)boronic acid is a white crystalline solid with a molecular weight of approximately 273.07 g/mol. It is slightly soluble in water and ethanol. The compound is moderately reactive, particularly in its ability to form boronate esters. It is known for its high reactivity with phenols and its use in various synthetic applications.

(1-Chloro-4-isoquinolinyl)boronic acid is typically synthesized via the reaction of 1-chloro-4-isoquinoline with boronic anilide under basic conditions. The process involves the use of sodium carbonate or potassium carbonate as a base and often requires mild heating. The yield is generally good, and the method is known for its high selectivity and reproducibility.

(1-Chloro-4-isoquinolinyl)boronic acid finds applications in the pharmaceutical industry for the synthesis of drug intermediates, particularly those involved in chemotherapy. It is also used in the polymer industry for the modification of polymers and in the development of sensors due to its reactivity and functional group availability. Additionally, it has potential use in semiconductor applications for specific chemical modification processes.

When handling (1-Chloro-4-isoquinolinyl)boronic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation of the compound. In case of spills, immediately clean up using appropriate absorbents and dispose of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.