5-(Trifluoromethyl)-2-pyridinecarboxylic acid(CAS: 80194-69-0)

5-(Trifluoromethyl)-2-pyridinecarboxylic acid has a crystalline form at room temperature with a molecular weight of approximately 217.08 g/mol. It is slightly soluble in water but soluble in organic solvents. This compound is known for its high reactivity, particularly towards nucleophilic substitution reactions. It reacts readily with amines and alcohols to form amides and esters, respectively.

5-(Trifluoromethyl)-2-pyridinecarboxylic acid is typically synthesized via the Friedel-Crafts acylation of 2-pyridinecarboxylic acid with trifluoroacetyl chloride in the presence of aluminum chloride as a catalyst. This process provides a high yield and good selectivity for the trifluoromethyl substitution.

5-(Trifluoromethyl)-2-pyridinecarboxylic acid is used in various industries including pharmaceuticals for the synthesis of drug candidates, in polymers for the development of advanced materials, and in sensors for their high sensitivity to certain chemical compounds. It is also used in the semiconductor industry for etching processes.

When handling 5-(Trifluoromethyl)-2-pyridinecarboxylic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and lab coats to prevent skin and eye contact. Work should be performed in a well-ventilated area, ideally in a fume hood, to avoid inhalation. In case of a spill, immediately clean it up with appropriate absorbents and follow the safety data sheet (SDS) for disposal instructions.