tert-butyl 4-aminobenzoate(CAS: 18144-47-3)

Tert-butyl 4-aminobenzoate (CAS: 18144-47-3) is a white crystalline solid with a molecular weight of 228.27 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is moderately reactive towards bases and nucleophiles. It exhibits good thermal stability and is stable under normal storage conditions.

Tert-butyl 4-aminobenzoate is typically synthesized via the reaction of 4-bromobenzoic acid with tert-butylamine in the presence of a suitable base like sodium hydride. The product is isolated by recrystallization from an appropriate solvent. The reaction is highly selective and provides a yield of about 75-85%.

Tert-butyl 4-aminobenzoate (CAS: 18144-47-3) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various drug molecules. It is also used in the polymer industry for improving the thermal stability of polymers. Additionally, it finds applications in the production of sensors and as a chemical reagent.

When handling tert-butyl 4-aminobenzoate (CAS: 18144-47-3), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Store the compound in a cool, dry place away from direct sunlight and heat sources. Use a fume hood when performing operations that may generate airborne particles. In case of a spill, handle it in accordance with the Material Safety Data Sheet (MSDS) guidelines, and seek medical attention if necessary.