2-Bromo-1-fluoro-4-nitrobenzene(CAS: 701-45-1)

2-Bromo-1-fluoro-4-nitrobenzene is a crystalline solid with a molecular weight of 241.01 g/mol. It has limited solubility in water but is more soluble in organic solvents like ethanol and acetone. This compound is highly reactive due to the presence of electron-withdrawing groups, making it prone to redox reactions and nucleophilic substitution. It is typically stored in a dry, cool place away from moisture and heat.

2-Bromo-1-fluoro-4-nitrobenzene can be synthesized via bromination of 1-fluoro-4-nitrobenzene followed by bromination. Commonly, bromine in the presence of a Lewis acid like aluminum tribromide is used. The reaction is typically carried out under anhydrous conditions to prevent side reactions. The yield is usually around 75-80%, and the product can be purified by recrystallization.

2-Bromo-1-fluoro-4-nitrobenzene is used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also finds applications in organic synthesis as a versatile starting material for the preparation of other functionalized derivatives. In the polymer industry, it serves as a monomer precursor for the development of novel materials. Additionally, it has potential applications in sensor technology and as a building block in semiconductor manufacturing.

When handling 2-Bromo-1-fluoro-4-nitrobenzene, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat is essential. The compound should be stored in a sealed container in a well-ventilated area. Spills should be handled with caution, using appropriate safety measures. In case of inhalation, seek medical attention immediately. Always consult the Safety Data Sheet (SDS) for specific guidelines on storage, handling, and emergency procedures.