Disodium 2'-deoxy-5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine(CAS: 72003-83-9)

Disodium 2'-deoxy-5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine (CAS: 72003-83-9) is a crystalline compound with a molecular weight of approximately 836.32 g/mol. It is poorly soluble in water and ethanol but soluble in organic solvents like dimethyl sulfoxide (DMSO). This compound exhibits moderate reactivity, particularly in the presence of acids or bases, and is susceptible to hydrolysis.

Disodium 2'-deoxy-5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine is synthesized through a multi-step process involving the condensation of 2'-deoxyadenosine with a phosphite ester. This reaction is typically catalyzed by a metal complex such as palladium(II) acetate. The overall yield is moderate, and the method is known for its high selectivity, ensuring the formation of the desired phosphorothioate derivative.

Disodium 2'-deoxy-5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine (CAS: 72003-83-9) finds application in the pharmaceutical industry, particularly in the development of antisense oligonucleotides and phosphorothioate analogs. It is also used in the field of molecular biology for labeling and studying RNA degradation mechanisms.

When handling Disodium 2'-deoxy-5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine (CAS: 72003-83-9), it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Handle the compound in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate absorbent material, and proper disposal methods should be followed. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.