Compound Q&A
How is Disodium 2'-deoxy-5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine (CAS: 72003-83-9) typically synthesized?
Answer
![Disodium 2'-deoxy-5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine](https://static.chemtradehub.com/structs/720/72003-83-9-5c69.webp "Disodium 2'-deoxy-5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine")
Disodium 2'-deoxy-5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine is synthesized through a multi-step process involving the condensation of 2'-deoxyadenosine with a phosphite ester. This reaction is typically catalyzed by a metal complex such as palladium(II) acetate. The overall yield is moderate, and the method is known for its high selectivity, ensuring the formation of the desired phosphorothioate derivative.
About
CAS No
72003-83-9
English Name
Disodium 2'-deoxy-5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine
Molecular Formula
C10H13N5Na2O9P2
Molecular Weight
455.17 g/mol
SMILES
C1C(C(OC1N2C=NC3=C(N=CN=C32)N)COP(=O)([O-])OP(=O)(O)[O-])O.[Na+].[Na+]
InChIKey
QPOQRKUWBIAHBO-OJSHLMAWSA-L
Last Updated: 2025-10-10 13:51
![查看HuBeiYongKuo Technology Co Ltd的Disodium 2'-deoxy-5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine](https://static.chemtradehub.com/suppliers/67cecc092b2de6e8e95a5bbd/67cecc092b2de6e8e95a5bbd-logo.webp){kind=logo}
![查看Hubei Dahao Chemical Co., Ltd.的Disodium 2'-deoxy-5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine](https://static.chemtradehub.com/suppliers/67ce362d57537e5c8069b51b/67ce362d57537e5c8069b51b-logo.webp){kind=logo}