4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isoindolinone(CAS: 765948-78-5)

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isoindolinone is a crystalline compound with a molecular weight of approximately 324.37 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMF and DMSO. Chemically, it is stable under normal conditions but reacts with strong acids and bases. It can be used in synthesis as a boron-containing reagent.

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isoindolinone is synthesized via a multi-step process involving the protection of 1-isoindolinone, followed by the introduction of a boron-containing group. Commonly, this involves using Boc-protected 1-isoindolinone and a boronic acid in the presence of a catalytic amount of palladium, a base, and a suitable solvent.

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isoindolinone is utilized in pharmaceuticals for its role as a building block in medicinal chemistry. It also finds application in the synthesis of polymers and sensors, particularly in the development of boron-containing materials for electronic and optical applications.

Handling 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isoindolinone requires the use of personal protective equipment (PPE) including gloves, goggles, and lab coat. Work in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up using appropriate decontamination procedures, and the Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.