(2E)-3-(2,3,4-Trifluorophenyl)acrylic acid(CAS: 207742-85-6)

(2E)-3-(2,3,4-Trifluorophenyl)acrylic acid has a crystalline form, a molecular weight of approximately 214.08 g/mol, and poor water solubility. It exhibits moderate reactivity, particularly towards nucleophiles, and is sensitive to moisture and light.

(2E)-3-(2,3,4-Trifluorophenyl)acrylic acid is typically synthesized via a Friedel–Crafts alkylation reaction of 2,3,4-trifluorophenylacetylene with acrylic acid. This process involves the use of a Lewis acid catalyst and requires careful control of temperature and pressure to achieve high yield and selectivity.

(2E)-3-(2,3,4-Trifluorophenyl)acrylic acid finds applications in pharmaceuticals for drug synthesis, polymers for advanced materials, and sensors for detecting various chemicals. It is also used in the development of semiconductors for electronic applications.

When handling (2E)-3-(2,3,4-Trifluorophenyl)acrylic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a fume hood and avoid contact with moisture and light. In case of a spill, immediately contain it and follow the safety data sheet (SDS) guidelines for disposal.