Ethyl 4-acetamido-3-hydroxybenzoate(CAS: 1346604-18-9)

Ethyl 4-acetamido-3-hydroxybenzoate is a crystalline solid with a molecular weight of approximately 276.29 g/mol. It has a solubility of about 3.5 g/L in water at 25°C. The compound is moderately reactive, especially under basic conditions. It is stable under normal storage conditions but should avoid contact with strong acids and bases.

Ethyl 4-acetamido-3-hydroxybenzoate is synthesized by the acetylation of 4-amino-3-hydroxybenzoic acid with ethyl acetoacetate in the presence of an acid catalyst such as sulfuric acid. The reaction is typically carried out at elevated temperatures, and the product is purified through recrystallization from an appropriate solvent.

Ethyl 4-acetamido-3-hydroxybenzoate finds applications in the pharmaceutical industry, where it serves as an intermediate in the synthesis of various drugs. It is also used in the production of organic pigments and dyes due to its color properties. Limited data suggests its use in the sensor industry for specific chemical detection applications.

When handling Ethyl 4-acetamido-3-hydroxybenzoate, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation risks. Spills should be cleaned up carefully using appropriate absorbents, and the area should be thoroughly rinsed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.