![N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure](https://static.chemtradehub.com/structs/101/1013920-15-4-a4c8.webp "N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure")
N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
CAS Number:
1013920-15-4
Molecular Formula:
C23H26FN5O3
N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide | CAS No. 896133-95-2
N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide
Basic Information
CAS Number
896133-95-2
Molecular Formula
C8H14N2O3
Molecular Weight
186.21 g/mol
AD
Basic Physical Properties
Synonyms & References
English
- Nicorandil Impurity 22
- 3-Pyridinecarboxamide, 1,6-dihydro-N-(2-hydroxyethyl)-6-oxo-
- Nicorandil Impurity 36
- 1,6-Dihydro-N-(2-hydroxyethyl)-6-oxo-3-pyridinecarboxamide (ACI)
- N-(2-Hydroxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
FAQ
What are the physical and chemical properties of N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide (CAS: 896133-95-2)?
N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide is a white crystalline solid with a molecular weight of approximately 221.26 g/mol. It has a pKa of around 8.2. The compound is moderately soluble in water and ethanol. It shows good reactivity with carboxylic acid derivatives and can form esters under appropriate conditions. It is a stable compound under normal storage conditions, but may degrade upon exposure to strong acids or bases.
How is N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide (CAS: 896133-95-2) typically synthesized?
N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide is typically synthesized via the condensation of 6-oxo-3-piperidinecarboxaldehyde with 2-hydroxyethylamine. The reaction is catalyzed by a Lewis acid like aluminum chloride and proceeds with good selectivity and yield. The final product can be purified by recrystallization from a suitable solvent like ethanol.
What industries use N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide (CAS: 896133-95-2)?
N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds application in the polymer industry as a stabilizer and in the formulation of certain coatings. Additionally, it is used in the development of sensors and as a component in some semiconductor materials.
What precautions should be taken when handling N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide (CAS: 896133-95-2)?
When handling N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and protective clothing. It should be used in a well-ventilated area or within a fume hood. Spills should be immediately cleaned up using suitable absorbents. In case of exposure, seek medical attention. The safety data sheet (SDS) should be consulted for detailed information on handling and storage.
Related Compounds
![7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure](https://static.chemtradehub.com/structs/101/1016505-59-1-4c54.webp "7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure")
7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS Number:
1016505-59-1
Molecular Formula:
C8H7N3O2
![2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure](https://static.chemtradehub.com/structs/104/1048919-15-8-ba81.webp "2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure")
2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid
CAS Number:
1048919-15-8
Molecular Formula:
C12H14FNO4
1,5,8-Trihydroxy-3-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
CAS Number:
110187-11-6
Molecular Formula:
C19H18O6
![9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure](https://static.chemtradehub.com/structs/119/1198286-24-6-4781.webp "9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure")
9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride
CAS Number:
1198286-24-6
Molecular Formula:
C16H26Cl2N2
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